The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. The Comfort Inn and Suites Chillicothe hotel in Chillicothe, MO near Poosey State Forest will get you rested and ready for anything. Conveniently located right off Highway 35, this hotel is near other sites and activities like General John J. Pershing Boyhood Home State Historic Site, Locust Creek Covered Bridge State Historic Site, J.C. Penney Museum and the Grand River Historical Society Museum. Amenities include free WiFi, flat-screen TVs, microwaves, refrigerators, coffee makers and pillow-top mattresses. In addition, we also have an indoor heated pool and a fitness center. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program. No Pets.