The Hampton Inn Greenville I-385 - Woodruff Rd. hotel is located in the heart of Greenville, South Carolina. The hotel is near the growing business centers and some of the areas newest restaurants and attractions. Our hotel features all the comforts of South Carolina and amenities that you expect from a Hampton Inn hotel with special touches such as: delivery of The Greenville News to your door every morning, a complimentary pass to the Sports Club, and the Hampton Inn signature breakfast, including hot menu. The Hampton Inn Greenville I-385 - Woodruff Rd. hotel is located in the heart of Greenville, South Carolina.