The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great stay is a great night at the Comfort Inn and Suites - Hannibal hotel in Hannibal, MO conveniently located near Rockcliffe Mansion. We are near Mark Twain Riverboat, Mark Twain Museum, Cameron Cave, Sawyers Creek Fun Park and more. Enjoy amenities like a grab and go breakfast, free WiFi, indoor heated pool, fitness room, guest laundry and much more. Rooms include microwaves, sofa beds, hair dryers and more. Earn rewards with every stay with our Choice Privileges Rewards program.