The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Located off Interstate 41, the Comfort Inn hotel in Henderson, KY is near the Ohio River on the Kentucky-Indiana border, just 25 minutes from Evansville Regional Airport. That makes our hotel an ideal lodging destination when visiting University of Evansville, University of Southern Indiana, the Ford Center and many other key businesses. We help get you rested and ready for anything in our inviting, spacious guestrooms. Each room features an HDTV, refrigerator, microwave, coffee maker, hair dryer, iron and ironing board. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.