The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Have a great stay at the Comfort Inn Mechanicsburg - Harrisburg South hotel in Mechanicsburg, PA. We are located off Route 15 along the Pennsylvania Turnpike, just minutes from the State Capitol Complex in Harrisburg. As a business traveler, you can enjoy amenities such as free WiFi, free hot breakfast, a fitness center and outdoor pool. Behind your great stay is a great night in one of our inviting guest rooms, all of which feature refrigerators, microwaves, coffee makers and hair dryers. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.