The Hampton Inn closest to Universal Orlando hotel is the closest to most major thruways in Orlando, Florida. It is the hotel of choice for business and leisure travel. In addition to easy access to major thruways, we are minutes away from most Orlando area attractions including Disney, SeaWorld, Wet 'n Wild, and The Holy Land Experience. Visiting the area for an event at The Amway Arena, Bob Carr Performing Arts Center, Hard Rock Café, House of Blues or UCF Arena? Our Hampton Inn hotel is minutes away from each location.