The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Get together for leisure or business at the Comfort Inn and Suites Orange County John Wayne Airport hotel in Santa Ana, CA. Our smoke-free hotel is minutes from Orange County beaches and were near Irvine Spectrum Center, Anaheim Convention Center, Fashion Island Newport Beach and Orange County Performing Arts Center. Our complimentary amenities include free WiFi and guest laundry facilities. Each comfortable guest room features a refrigerator, microwave, coffee maker and hair dryer. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.