IHG One Rewards. It's better to be a member. Join IHG One Rewards to unlock benefits that will immediately enhance your next stay. Welcome to our brand new Holiday Inn Express in Chesterfield, MO! Our Chesterfield, MO hotel is conveniently located on I-64 just off exit 17 and only 23 miles west of downtown St. Louis. Business travelers will appreciate our hotel location near major companies such as St. Luke's Hospital, Pfizer, Crown Packaging, Instituform, Monsanto, Reinsurance Group of America and Amdocs. Staying at Holiday Inn Express & Suites St. Louis-Chesterfield will make it easier to visit popular area attractions like Six Flags, St. Louis Amusement Park, Gateway Motorsports Park, Anheuser Busch Brewery, St. Louis Gateway Arch, St Louis Zoo, Splash City and Fairmont Horse Track. You'll feel welcomed the moment you enter the lobby of the new Holiday Inn Express & Suites St. Louis-Chesterfield. We take pride in providing clean, comfortable lodging and attentive service. Regardless of whether youre staying at our hotel on business or pleasure you can expect a warm and thoughtful staff dedicated to making you feel right at home. The Holiday Inn Express & Suites St. Louis-Chesterfield offers 91 well-appointed guest rooms. Additional hotel amenities include free high-speed wireless Internet access complimentary Fresh Start breakfast bar daily 24/7 Business Center and meeting space along with an indoor pool and fitness room featuring the latest equipment.