The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Enjoy a simply stylish experience at the Sleep Inn And Suites in Hannibal, MO. Our affordable, smoke-free hotel is conveniently located off I-72, providing easy access to Hannibal Regional Airport and Hannibal Regional Hospitals and Clinics. We offer a contemporary interior design and a host of amenities including a business center, free WiFi, free hot breakfast, fitness center, indoor heated pool, guest laundry facilities and more. All guestrooms feature coffee makers, microwaves, refrigerators, hair dryers, 39-inch flat-screen TVs, irons and boards. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.