IHG One Rewards. It's better to be a member. Join IHG One Rewards to unlock benefits that will immediately enhance your next stay. Welcome to the Holiday Inn Express Hotel & Suites Las Cruces. Enjoy a relaxing stay in our beautiful Las Cruces Holiday Inn Express Hotel & Suites near New Mexico State University and just a few minutes from historic Old Mesilla. Families enjoy this Southern New Mexico hotel because of our great location near New Mexico State University, and because we are conveniently located just off I-10 and I-25 with easy access to nearby Las Cruces attractions. These attractions include Historic Old Mesilla, the New Mexico Farm & Ranch Heritage Museum and the Las Cruces Farmers & Crafts Market. Leisure travelers can shop at nearby Mesilla Valley Mall or the historic Old Mesilla Plaza, featuring over 40 Southwestern craft shops. Lodging in Las Cruces puts you in the center of the Old West's history. Why settle for cheap lodging in Las Cruces, New Mexico when you can enjoy our comfortable and smoke free hotel near Old Mesilla? Business travelers will appreciate our close location to New Mexico State University, as well as our meeting rooms, free high-speed Internet access and a 24-hour business center with copy, print and fax services. Our Southern New Mexico hotel provides a complimentary hot breakfast bar, a well-equipped, 24-hour fitness center and an indoor, heated pool with and spa. Book your reservations now and take advantage of our great Las Cruces hotel deals and rates for your next stay in sunny New Mexico.