The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great day is a great night at the Comfort Inn and Suites Macon hotel in Macon, MO. Our convenient location at the junction of Highways 63 and 36 makes this smoke-free hotel an ideal lodging choice. Business travelers appreciate our meeting space and copy and fax services, as well as complimentary amenities like daily hot breakfast, a fitness center, indoor heated pool, laundry facilities and parking for vehicles of any size, including RVs. Each guest room features a 50-inch LCD flat-screen TV, refrigerator, microwave, coffee maker and hair dryer. Also, earn rewards including free nights and gift cards with our Choice Privileges Rewards program.