Frank began his career as a precocious teenager creating large-scale photorealist paintings, though by the time of his first exhibitions in New York, he was a pioneer in the use of video creating groundbreaking installations of video sculpture. Following a period of 'appropriation' paintings on plywood (1993-98) Frank developed a series of works based on abstracted motifs drawn from Nixon and Kissinger, the latter politician being photographed before his eponymous painting at the Four Seasons restaurant. Most recently Frank has become best known for lyrical and seemingly abstract drawings and large-scale paintings, though he continues to use life models in his studio to create these works.
Frank has exhibited his work with a range of galleries including Salvatore Ala, Danese, Valeria Belvedere, Postmasters, Paul Kasmin, and Tim Olsen in Sydney and at both the Fodor and the Merchant's House in his native Amsterdam.