About Presque Isle Comprehensive Treatment Center in Presque Isle, ME Presque Isle Comprehensive Treatment Center (CTC), located in Presque Isle, Maine, provides outpatient medication-assisted treatment for adults age 18 and older of all genders who are struggling with opioid addiction. Medication-assisted treatment, or MAT, is an evidence-based, scientifically proven form of opioid addiction treatment that uses both prescription medication and counseling. It is considered both a safe and effective way to treat opioid addiction and has been used at methadone clinics across the United States for several decades.