The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Behind every great day is a great night at the pet-friendly Comfort Inn and Suites Sikeston I-55 hotel in Sikeston, MO. We are conveniently located right near activities and sites like the VF Factory Outlet Mall, Bootheel Golf Club, Sikeston Depot, Veterans Park and Beggs Family Farm. Take advantage of our free hot breakfast, free WiFi, free coffee and guest laundry facilities. Rooms feature flat-screen TVs, hair dryers, coffee makers, irons and ironing boards, microwaves and refrigerators. We also offer membership to the Choice Privileges Program, which gives members the opportunity to earn valuable rewards points toward airline miles, gift cards and free hotel room nights.