The well-being of guests is top of mind at Choice-branded hotels. Guests may experience a variety of new, improved cleanliness protocols and products. Enjoy an easy stop on the road in Yankton, SD when you stay at our smoke-free Comfort Inn Yankton SD hotel. We are close to the Yankton Mall, Gavins Point Dam, Lewis and Clark Specialty Hospital, Avera Sacred Heart Hospital and Shur-Co of South Dakota. Each guest can enjoy our free breakfast, free WiFi, free weekday newspaper and free coffee. Unwind in one of our guest rooms, all of which feature a refrigerator, microwave, hair dryer and 32 inch flat-screen TV. Sign up today for our Choice Privileges program and start earning rewards points with your next stay. Some amenities may require an additional cost.