De La Salle Health Sciences Institute is one of the member schools of the De La Salle Philippines which is affiliated with the worldwide network of Lasallian schools managed by the Brothers of the Christian Schools, a Catholic religious congregation founded by Saint John Baptist de La Salle. As a member of the Philippine Lasallian Family, it embraces the guiding principles and core values of Spirit of Faith, Zeal in Service, Communion in Mission, and Reverence for Life.