Founded and formally inaugurated during the 19th anniversary celebration of the Manila Doctors Hospital (MDH) in 1975 and first known as the MDH School of Nursing, the Manila Doctors College was originally located at the fourth floor of the MDH along United Nations Avenue. Some of its founding members include Dr. Ambrosio Tangco, Dr. Gonzalo F. Austria, Dr. Fidel Estrada, Dr. Jose Villanueva and other members of the Board of Directors of the Hospital.